We suggest that such higher-order architectures could serve as platforms for sophisticated devices that co-ordinate the activity of numerous transmembrane molecular machines. Finally, we highlight higher-order compartmentalised systems that exhibit emergent properties. We chart the development of man-made transmembrane systems from passive to machine-like stimuli-responsive channels, to fully autonomous transmembrane molecular machines. We illustrate the importance of surfaces for facilitating the extraction of work from molecular switches and motors. Man the molecule, phantasmal thanatology, by Charles Edgar De Angurre Year of. 20 April 19237 March 2000 Brief Life History of Charles Edgar When Charles Edgar Miller was born on 20 April 1923, in Shelbyville, Shelby, Missouri, United States, his father, William Earl Miller, was 32 and his mother, Goldia Ethyl Selby, was 26. This tutorial review opens by highlighting seminal examples of synthetic molecular machines. Man the molecule, phantasmal thanatology, by Charles Edgar De Angurre. Indeed, the realisation of such principles in synthetic transmembrane systems remains a tantalising goal. Many of these molecular machines function within lipid membranes, allowing them to exploit potential gradients between spatially close, but chemically distinct environments to fuel their work cycle. Nature's molecular machines are a constant source of inspiration to the chemist.
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